Astragalus
Preclinical data suggests the polysaccharides found
in astragalus (Astragalus membranaceus) can improve
organ weight, improve the proliferation of B and T
lymphocytes, regulate natural killer cells, and help to
reduce insulin resistance.[1]
Reishi
Reishi (Ganoderma lucidum) contains polysaccharides
and beta-glucans that activate a series of
immunomodulating compounds, enhance the
maturation of dendritic cells, and increase natural
killer-cell activity.[2]
A meta-analysis of five clinical trials with 373
patients was used to assess the efficacy of reishi
in lung cancer.[2] Two clinical studies were found
for Ganoderma in conjunction with chemotherapy/
radiotherapy that demonstrated lung-cancer patients
responded more positively than those who did not
receive reishi, and another study demonstrated
that reishi improved leukocyte depletion from
chemotherapy. In four studies, reishi improved
quality of life as per the Karnofsky score, an effect
which was statistically significant in three of the four
studies. According to the review, only three reports
of toxicity with reishi were found: two cases of
nausea, and one case of insomnia. No other hepatic,
hematopoietic, or biochemistry abnormalities were
observed.
Coriolus versicolor
The immunomodulatory effects of Coriolus versicolor
(also known as Trametes versicolor) are based on its
polysaccharide content, which has been shown to
stimulate tumour necrosis factor-α (tumour-cell
apoptosis), increase natural killer cell (antitumour
effects), and increase superoxide dismutase (regulates
oxidative stress).[3] A systematic review and metaanalysis of 13 clinical trials found that Coriolus as
an adjunctive therapy to chemotherapy improved
overall survival at 5 years, especially in breast cancer,
gastric cancer, and colorectal cancer, compared to chemotherapy alone (p < 0.00001).[4] They found an absolute reduction in 5-year mortality, which signifies that one additional patient lived out of 11 treated. A systematic review and meta-analysis, consisting of 23 randomized controlled trials involving 4,246 cancer patients, aimed to evaluate the efficacy and safety of Coriolus versicolor and reishi for cancer therapy. This study showed that both Coriolus versicolor and reishi extracts could significantly elevate the levels of CD3 and CD4 T cells. This improvement in CD3 and CD4 counts indicates that Coriolus versicolor and reishi can help reduce the immunosuppression of chemotherapy or radiation. The authors concluded that Coriolus versicolor– and reishi-related natural products may have potential benefits on the overall survival and quality of life of cancer patients.[5]
 
Each vegetable capsule contains:
Astragalus (Astragalus membranaceus)
root extract, 3% astragalosides IV. . . . . . . . . 166.7 mg
Reishi (Ganoderma lucidum) mushroom extract,
40% polysaccharides, 30% beta-glucans. . . . 166.7 mg
Coriolus (Trametes versicolor) mushroom extract,
55% polysaccharides, 50% beta-glucans. . . . 166.7 mg